Edited from Wikipedia
The Isenheim Altarpiece is an altarpiece painted by the German artist Matthias Grünewald between 1512 and 1516.
By far his greatest, as well as his largest work, it was painted for the Monastery of St. Anthony in Isenheim near Colmar (then in Germany), which specialized in hospital work. The Antonine monks of the monastery were noted for their treatment of sufferers of skin disease, such as ergotism, symptoms of which are displayed by figures including the crucified Christ in the altarpiece.
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